He opened The Practical Fly Shop in Little Neck, NY in 1992, where his customers encouraged him to create many of his innovative flies. That led him to experiment with more durable synthetic and natural materials to create flies that eventually became part of the catalog of offerings that are now marketed through Enrico Puglisi Ltd. as EP™ Flies and EP™ Fibers.
Today, Enrico no longer maintains The Practical Fly Shop, but through Enrico Puglisi Ltd., his innovative products are making a major impact on the future direction of saltwater fly fishing. His unique hand-tied flies are recognized around the world, and he has been invited to demonstrate his meticulous tying techniques across the United States and Europe. All of his patterns are designed to match specific baitfish and to be eminently fishable.